HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burdakov, D. Search for Related Content PubMed Articles by Burdakov, D.

Gain Control by Concerted Changes in I_A and I_H Conductances

denis.burdakov{at}man.ac.uk, Neurosciences Division, Biological Sciences, University of Manchester, Manchester M13 9PT, U.K.

Stability of intrinsic electrical activity and modulation of input-output gain are both important for neuronal information processing. It is therefore of interest to define biologically plausible parameters that allow these two features to coexist. Recent experiments indicate that in some biological neurons, the stability of spontaneous firing can arise from coregulated expression of the electrophysiologically opposing I_A and I_H currents. Here, I show that such balanced changes in I_A and I_H dramatically alter the slope of the relationship between the firing rate and driving current in a Hodgkin-Huxley-type model neuron. Concerted changes in I_A and I_H can thus control neuronal gain while preserving intrinsic activity.

This article has been cited by other articles:

				E. P. Cook, J. A. Guest, Y. Liang, N. Y. Masse, and C. M. Colbert Dendrite-to-Soma Input/Output Function of Continuous Time-Varying Signals in Hippocampal CA1 Pyramidal Neurons J Neurophysiol, November 1, 2007; 98(5): 2943 - 2955. [Abstract] [Full Text] [PDF]

				O. Khorkova and J. Golowasch Neuromodulators, Not Activity, Control Coordinated Expression of Ionic Currents J. Neurosci., August 8, 2007; 27(32): 8709 - 8718. [Abstract] [Full Text] [PDF]

				J. Triesch Synergies between intrinsic and synaptic plasticity mechanisms. Neural Comput., April 1, 2007; 19(4): 885 - 909. [Abstract] [Full Text] [PDF]