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Unsupervised Spike Detection and Sorting with Wavelets and Superparamagnetic Clustering

rodri{at}vis.caltech.edu, Division of Biology, California Institute of Technology, Pasadena, CA 91125, U.S.A.

Z. Nadasdy

zoltan{at}vis.caltech.edu, Division of Biology, California Institute of Technology, Pasadena, CA 91125, U.S.A.

Y. Ben-Shaul

ybss{at}md.huji.ac.il, ICNC, Hebrew University, Jerusalem, Israel

This study introduces a new method for detecting and sorting spikes from multiunit recordings. The method combines the wavelet transform, which localizes distinctive spike features, with superparamagnetic clustering, which allows automatic classification of the data without assumptions such as low variance or gaussian distributions. Moreover, an improved method for setting amplitude thresholds for spike detection is proposed. We describe several criteria for implementation that render the algorithm unsupervised and fast. The algorithm is compared to other conventional methods using several simulated data sets whose characteristics closely resemble those of in vivo recordings. For these data sets, we found that the proposed algorithm outperformed conventional methods.

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